Xeno‐free Cultivated Limbal Epithelial Stem Cell Transplantation: result of an ongoingphase I/II clinical study
نویسندگان
چکیده
منابع مشابه
Phenotypic study after cultivated limbal epithelial transplantation for limbal stem cell deficiency.
OBJECTIVE To report phenotypic analysis of epithelia before and following cultivated limbal epithelial transplantation (CLET) for eyes with limbal stem cell deficiency. METHODS Six patients with limbal stem cell deficiency (3 with alkali burns, 2 with Stevens-Johnson syndrome, and 1 with pseudo-ocular cicatricial pemphigoid) were subjected to CLET and subsequent keratoplasty. Immunohistochemi...
متن کاملEarly Results of Autologous Cultivated Limbal Stem Cell Transplantation in Total Limbal Stem Cell Deficiency
Purpose: To report the early results of transplantation of autologous limbal stem cells cultivated on amniotic membrane (AM) in patients with total unilateral limbal stem cell deficiency (LSCD). Methods: Four eyes of 4 patients with total unilateral LSCD confirmed with impression cytology underwent transplantation of autologous limbal stem cell cultivated on AM. At each follow up visit, a compl...
متن کاملearly results of autologous cultivated limbal stem cell transplantation in total limbal stem cell deficiency
purpose: to report the early results of transplantation of autologous limbal stem cell cultivated on amniotic membrane in total limbal stem cell deficiency. methods: four eye of 4 patients with total unilateral stem cell deficiency secondary to severe chemical or thermal burn were included. stem cell deficiency was confirmed with impression cytology in all cases. under topical anesthesia, a sma...
متن کاملA Case of Autologous Cultivated Limbal Stem Cell Transplantation
The patient presented herein, is a 29-yearold man with history of unilateral alkaline chemical injury 14 years ago. Upon referral, visual acuity was 20/20 and the examination was unremarkable in the right eye. Vision was hand motions (HM) in his left eye and a small angle exotropia (10-15 Prism Diopters) was evident. Slitlamp examination revealed severe corneal opacification and vascularization...
متن کاملCultivated limbal stem cell transplantation for ocular surface reconstruction
Severe damage to cell repair mechanisms of the limbal region can lead to many disorders such as vascularized conjunctivalization, keratinization, corneal scarring, and corneal opacification, collectively described as limbal stem cell deficiency (LSCD). Limbal stem cell deficiency may occur as a result of depletion of stem cells or destruction of their stromal niche. In such cases, apart from co...
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ژورنال
عنوان ژورنال: Acta Ophthalmologica
سال: 2019
ISSN: 1755-375X,1755-3768
DOI: 10.1111/j.1755-3768.2019.8136